South African Scientists Claim Breakthrough Drug Cures All Strains of Malaria
Plasmodium Falciparum in the Blood
IMAGE BY CDC via Wikimedia
Malaria is the scourge of tropical nations, crippling its victims with symptoms like debilitating fever, convulsions and nausea, and killing half a million people annually. Now researchers in South Africa say they may have a one-size-fits-all solution, in the form of a new drug that could work with just one dose.
The drug is a synthetic molecule in a class of compounds known as aminopyridines, which are precursors to many drugs for neurological disorders. Scientists at Australia's Griffith University were screening more than 6 million drug compounds and suggested aminopyridine for further study. Then a team of scientists led by Kelly Chibale at the University of Cape Town tested several of these compounds, settling on a suitable molecule that will now be tested further.
Most cases of malaria in Africa are caused by a parasite called Plasmodium falciparum, which lives in the salivary glands of female mosquitoes and is transferred into the human bloodstream when the bug bites.